Evidence map›Paper›PMID 41488776›Full record

ArticleiScience2026

CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity.

Dong-Mei Wang, Juan Yang, Mohammad Owais Ansari, Zarema Arbieva, Mark Maienschein-Cline, Viswanathan Natarajan, Asrar B Malik, Chinnaswamy Tiruppathi

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Dong-Mei WangDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Juan YangDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Mohammad Owais AnsariDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Zarema ArbievaGenomics Research Core, Research Resources Center, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Mark Maienschein-ClineResearch Informatics Core, Research Resources Center, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Viswanathan NatarajanDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Asrar B MalikDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Chinnaswamy TiruppathiDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
The Lung Endothelium as an Instructive Niche for the Innate Immune System during Vascular InjuryP01HL160469 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 2022 to 2026
$14.0M
Transcription Factor Elf2 Signals Resolution of Lung InjuryR01HL156965 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI TIRUPPATHI, CHINNASWAMY · 2021 to 2024
$2.1M
NCATS NIH HHS UL1 TR002003NHLBI NIH HHS P01 HL160469NHLBI NIH HHS R01 HL156965
6 · The paper itself

Abstract

The Ets transcription factors induce the expression of Tie2 and VE-cadherin. However, the regulation of these factors remains unknown. Here, we found that the gene encoding the Ets factor Elf2 was hypermethylated in Camkkβ-deficient (

Indexed as

BiochemistryCell biologyMolecular biology

Identifiers

PMID41488776
PMCPMC12757589

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.