ReviewiScience2026
The neuroimmune axis and chronic pain disorders.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Not All Microbiomes Reflect Chronic Pain: Evidence from the Urinary Tract in a Case-Control Study.Journal of clinical medicine · 2026Article
- A new paradigm: 46 structural cell types function as environment-supporting innate immune cells, with endothelial and vascular smooth muscle cells as key prototypes.iNew medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both the nervous system and the immune system alert and protect the body against pathogen invasion and damage, but the extent of their interactions have only truly been elaborated in the past few decades. Lymph nodes (LN) are essential immune command centers that modulate the adaptive immune response through the integration of a multitude of signals and activation of T and B lymphocytes. LN are also known to be innervated by sympathetic and sensory nerves. While sympathetic regulation of the immune system is well-established, the impact of sensory neurons has been overlooked. Recently, the sensory neuronal population that innervates popliteal LN has been described in detail, with most cells characterized as peptidergic nociceptors. Of further interest, patients suffering with pain disorders like fibromyalgia, complex regional pain syndrome (CRPS) and hereditary sensory and autonomic neuropathies (HSAN) display both immune and autonomic dysfunction. The localization of nociceptors on LN indicates that there may be a larger impact of sensory neuronal signaling on adaptive immunity than has been explored currently. Therefore, this paper investigates the impact of neural signaling on immunity, specifically the LN and its main cell populations, and aims to address the gaps in our understanding of immune problems featured in pain disorders with aberrant or absent pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.