Evidence map›Paper›PMID 41488766›Full record

ReviewInternational journal of women's health2025

Development and Application of Tumor Organoids: An Emerging Platform for Gynecological Cancers.

Yu Hu, Wei Chen, Xiaojing Zhang, Ying Wu, Furong Du, Jingrui Wang, Meijun He, Wei Sun

Abstract readReview
In one paragraph

Review in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu Hu *Laboratory Department, the People's Hospital of Chuxiong Yi Autonomous Prefecture & the Fourth Affiliated Hospital of Dali University, Chuxiong, Yunnan, 675000, People's Republic of China.
Wei Chen *Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, 350014, People's Republic of China.
Xiaojing Zhang *Reproductive Health Research Institute, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan, 450000, People's Republic of China.
Ying WuDepartment of Obstetrics and Gynecology, the 920th Hospital of Joint Logistics Support Force, Kunming, Yunnan, 650032, People's Republic of China.
Furong DuDepartment of Medicine, Kingbio Medical Co., Ltd., Chongqing, 401123, People's Republic of China.
Jingrui WangDepartment of Medicine, Kingbio Medical Co., Ltd., Chongqing, 401123, People's Republic of China.
Meijun HeDepartment of Obstetrics and Gynecology, the 920th Hospital of Joint Logistics Support Force, Kunming, Yunnan, 650032, People's Republic of China.
Wei SunDepartment of General Internal Medicine, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, 030013, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gynecological cancers pose great health threats to women, in which ovarian cancer (OC), cervical cancer (CC) and endometrial cancer (EC) are most common. Conventional treatment modalities for gynecological cancers, such as surgery, chemotherapy and radiotherapy, are usually affected by multiple factors like drug resistance and recurrence. Organoids, a three-dimensional culture system derived from stem cells, have been demonstrated to recapitulate the biological structure and function of human organs and gradually used in the treatment of various cancer types, including gynecological cancers. The organoids established from gynecological cancers have patient tumor-dependent morphology and disease characteristics while retaining the tumor's marker expression and genomic profiling, and present heterogeneous inter- and intra-patient drug responses, offering novel insights into drug response of the individual patients. This review provides an overview of recent advancements in the development and application of organoids from gynecological cancers, promoting the understanding of the mechanism underlying tumorigenesis, drug screening prediction and personalized treatment application in gynecological cancers.

Indexed as

drug screeninggynecological cancersmolecular mechanismprecision medicinetumor organoids

Identifiers

PMID41488766
PMCPMC12764298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.