ArticleFrontiers in toxicology2025
Beyond cytotoxicity: pollutant mixtures elicit unconventional epithelial-fibroblast signaling in a human lung air-liquid interface co-culture model.
Article in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Combined trauma and toxic inhalation in war and disaster medicine: alveolar-capillary barrier failure and respiratory countermeasures.Critical care (London, England) · 2026Review
- The Impact of the Exposome on Epithelial Barriers: New Approach Methodologies for Translational Research.Thoracic research and practice · 2026Article
- From prediction to adaptation: rethinking the epistemic role of inhalation toxicology.Frontiers in toxicology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Combined exposures to airborne nanoparticles and acidic gases are plausible during industrial accidents and in military settings involving propellants. Aluminum oxide nanoparticles (Al Methods: Cells were exposed daily for four days, and epithelial viability, barrier integrity, and mediator release were assessed. Conditioned media from exposed cultures were applied to naïve fibroblasts to evaluate proliferation and migration responses. Results: Repeated exposures did not induce cytotoxicity, barrier disruption, or increases in canonical pro-fibrotic or pro-inflammatory mediators such as TGF-β1, CTGF, or IL-8. However, conditioned media from exposed epithelial cells consistently triggered fibroblast activation through non-canonical epithelial-mesenchymal signaling pathways. These effects occurred at sub-toxic exposure levels. Discussion: These findings indicate that early sub-lethal co-exposure to Al
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Registered trials
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