Trial reportDrug design, development and therapy2025
Effects of Remimazolam-Propofol Anesthesia on Recovery and Sleep Quality in Older Adult Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Repeated remimazolam sedation for interstitial brachytherapy in cervical cancer: a randomized controlled trial.Annals of medicine · 2026Trial
- Letter to the Editor Regarding "Effect of Remimazolam Versus Propofol Sedation on Postoperative Sleep Quality Following Gastroscopy: A Propensity Score-Matched Cohort Study" [Letter].Drug design, development and therapy · 2026Article
- Exploring the analgesic effect of artificial dura mater as a carrier for local hydromorphone delivery in posterior lumbar interbody fusion: a randomized controlled trial.Frontiers in pharmacology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Propofol and remimazolam monotherapy have their own limitations for general anesthesia in elderly patients. Optimizing anesthesia protocols is essential to enhance recovery and postoperative outcomes. This study aimed to evaluate the effects of combined sub-anesthetic doses of remimazolam and propofol on anesthesia recovery and sleep quality in this population. Patients and Methods: This single-center, single-blind, prospective, randomized controlled trial enrolled 92 patients aged 65-80 years scheduled for elective laparoscopic colorectal cancer surgery. Patients were randomly allocated to either group P (propofol alone, 4-12 mg/kg/h) or group PR (propofol 2-4 mg/kg/h combined with remimazolam 0.3 mg/kg/h). The primary outcome was awakening time. The secondary outcomes included sedation scores, intraoperative hemodynamics, postoperative Pittsburgh Sleep Quality Index (PSQI) scores, Visual Analogue Scale (VAS) scores, Quality of Recovery-15 (QoR-15) scores, and the incidence of adverse events. Results: Awakening time was significantly reduced in group PR compared with group P (14.8 ± 4.8 min vs 18.9 ± 5.1 min, Conclusion: Anesthesia maintenance using a sub-anesthetic dose of remimazolam combined with propofol was associated with shorter awakening time and improved postoperative recovery quality. This combination may represent a promising anesthetic strategy, but further research with objective sleep monitoring is warranted to confirm these findings.
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