ArticleJournal of current ophthalmology
Long-Term Outcomes of 10-Minute Accelerated Corneal Cross-Linking on Structural, Topographic, and Tomographic Corneal Parameters: A 5-Year Prospective Study.
Article in Journal of current ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
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Abstract
Purpose: To evaluate the long-term effects of accelerated corneal cross-linking (ACXL) in stabilizing progressive keratoconus (KC), as these effects remain unclear. Methods: This 5-year longitudinal study included 49 eyes with progressive KC who underwent 10-min ACXL. Baseline and posttreatment assessments included uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), refractive error (sphere, cylinder, and spherical equivalent), corneal curvature indices (maximum keratometry [Kmax], flat keratometry [K1], steep keratometry [K2], and mean keratometry), corneal thickness, and corneal irregularity indices (index of height asymmetry [IHA], index of surface variance [ISV], and inferior-superior value [IS-value]). Corneal imaging was performed using Pentacam and Corvis ST. Longitudinal changes were analyzed using repeated-measures statistical models. Results: Significant improvements were observed in UCVA and BCVA over time ( Conclusions: This study supports the long-term efficacy of 10-min ACXL in stabilizing progressive KC, with sustained improvements in corneal irregularity indices and visual function. Early 10-min ACXL intervention is recommended to be considered for maximizing stabilization and preventing advanced disease progression.
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