Evidence map›Paper›PMID 41488697›Full record

ReviewOpen forum infectious diseases2026

The Impact of

Nicola Luigi Bragazzi, Valerie Bosch Castells, Qi Deng, Grégoire Ranson, Edward Thommes, Jianhong Wu, Sandra S Chaves

Abstract readReview
In one paragraph

Review in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicola Luigi BragazziLaboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-8409-868X
Valerie Bosch CastellsSanofi, Lyon, France.ORCID https://orcid.org/0009-0003-8210-067X
Qi DengLaboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada.
Grégoire RansonLaboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada.
Edward ThommesSanofi, Toronto, Canada.
Jianhong WuLaboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-0052-5336
Sandra S ChavesSanofi, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: A systematic review and meta-analysis of case-control studies were conducted following PRISMA guidelines. Literature from PubMed/MEDLINE, Scopus, Cochrane, and Embase (2000 onward) was screened. Random-effects models were used in R, with subgroup analyses by geography, case definition, diagnostics, and matching criteria. Results: Out of 2941 records, 26 case-control studies (11 706 participants) met inclusion criteria. Most studies used molecular diagnostics (n = 23). A significant association was found between CT infection and male infertility (odds ratio [OR] 3.68 [95% CI 2.24-6.02]), with substantial heterogeneity ( Conclusions: While findings suggest that CT infection may impair male fertility, confounding, bias, and the lack of geographical representativeness limit inference. High-quality, large-scale prospective studies are needed to confirm causality and guide targeted interventions.

Indexed as

chlamydia trachomatismale infertilitymeta-analysisreproductive healthsystematic review

Identifiers

PMID41488697
PMCPMC12757865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.