SynthesisFrontiers in human neuroscience2025
Effect of deep brain stimulation on motor complications in Parkinson's disease: a systematic review and meta-analysis.
Synthesis in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Neuroprotective role ofFrontiers in nutrition · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Deep brain stimulation (DBS) significantly improves tremor, rigidity, bradykinesia, and dyskinesia for patients with Parkinson's disease (PD), but gait and speech remain inconsistent. These discrepancies underscore the need for a systematic, quantitative synthesis of existing data to clarify the impact of DBS across different motor domains. Objective: To systematically evaluate the effects of DBS on motor symptoms in PD by analyzing UPDRS-III scores and conducting subgroup analyses based on stimulation target, stimulation type, and medication status. Methods: A literature search was conducted to identify relevant studies on clinical trials and observational studies reporting pre- and post-DBS motor assessments in PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Ovid MEDLINE, and Web of Science from inception to 15 December 2024. Results: A total of 35 studies comprising 1,082 PD patients were included. The pooled analysis demonstrated a significant improvement in overall UPDRS-III scores post-DBS (WMD: = -1.09, 95% CI: -1.32 to -0.87, Conclusion: DBS significantly improves overall motor function, particularly tremor, rigidity, and bradykinesia. However, its effects on gait and speech remain inconsistent, which shows the need for further research to refine patient selection and optimize stimulation parameters. These findings provide valuable insights into the therapeutic impact of DBS in PD management.
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