Evidence map›Paper›PMID 41488650›Full record

ArticleFrontiers in immunology2025

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection.

Valerie Plajer, Adrián Madrigal-Avilés, Maria Dzamukova, Nayar Durán-Hernández, Philippe Saikali, Vivien Holecska, Isabel Panse, Katrin Lehmann, Jinfang Zhu, Mir-Farzin Mashreghi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Valerie PlajerCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Experimental Immunology and Osteoarthritis Research, Berlin, Germany.
Adrián Madrigal-AvilésCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Experimental Immunology and Osteoarthritis Research, Berlin, Germany.
Maria DzamukovaCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Experimental Immunology and Osteoarthritis Research, Berlin, Germany.
Nayar Durán-HernándezCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Experimental Immunology and Osteoarthritis Research, Berlin, Germany.
Philippe SaikaliCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Experimental Immunology and Osteoarthritis Research, Berlin, Germany.
Vivien HolecskaCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Experimental Immunology and Osteoarthritis Research, Berlin, Germany.
Isabel PanseCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Experimental Immunology and Osteoarthritis Research, Berlin, Germany.
Katrin LehmannTherapeutic Gene Regulation, German Rheumatology Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
Jinfang ZhuLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Mir-Farzin MashreghiTherapeutic Gene Regulation, German Rheumatology Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
Ahmed N HegazyCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Gastroenterology, Infectious Diseases and Rheumatology, Berlin, Germany.
Caroline PeineCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Experimental Immunology and Osteoarthritis Research, Berlin, Germany.
Max LöhningCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Experimental Immunology and Osteoarthritis Research, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virus-specific CD4

Indexed as

Lymphocytic ChoriomeningitisLymphocytic choriomeningitis virusTh1 CellsAnimalsImmunologic MemoryMiceMice, Inbred C57BLMice, TransgenicPersistent InfectionT-bet Transcription FactorT-Box Domain ProteinsT-bet Transcription FactorT-Box Domain ProteinsCD4 T cellschronic infectionexhaustionquantitative stabilityT-betTh1 cells

Identifiers

PMID41488650
PMCPMC12757370

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.