Evidence map›Paper›PMID 41488596›Full record

ArticleTrends in analytical chemistry : TRAC2024

Stable isotope ratio analysis: an emerging tool to trace the origin of falsified medicines.

Alberto Roncone, Simon D Kelly, Zoe Giannioti, Cathrin Hauk, Céline Caillet, Paul N Newton, Carla Perez-Mon, Luana Bontempo

Abstract read
In one paragraph

Article in Trends in analytical chemistry : TRAC, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alberto RonconeTraceability Unit, Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38098, San Michele All'Adige, TN, Italy.
Simon D KellyFood Safety & Control Laboratory, Joint FAO/IAEA Centre of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Vienna International Centre, Wagramer Strasse 5, P.O. Box 100, 1400, Vienna, Austria.
Zoe GianniotiTraceability Unit, Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38098, San Michele All'Adige, TN, Italy.
Cathrin HaukNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Céline CailletNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Paul N NewtonNDM Centre for Global Health Research, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Carla Perez-MonRoyal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Midlothian, EH25 9RG, United Kingdom.
Luana BontempoTraceability Unit, Research and Innovation Centre, Fondazione Edmund Mach, Via E. Mach 1, 38098, San Michele All'Adige, TN, Italy.

Funding

Wellcome Trust 222506
6 · The paper itself

Abstract

Falsified medicines pose a serious threat to global public health. Over the past few decades, the number of public health issues and seizures of falsified medicines has dramatically increased across the world. The development of new analytical techniques for the identification and traceability of these products hold great promise for innovation to help curtail the high number of deaths caused by the lack of adequate treatments and in combating the criminals responsible for manufacturing these products. This review presents the main approaches, based on stable isotope ratios of the bio-elements, mainly Isotope Ratio Mass Spectrometry and Site-specific Natural Isotopic Fractionation by Nuclear Magnetic Resonance, that can contribute to identifying the origin of these products, both in terms of geographical origin and raw materials employed as well as for the batch controls by the producers.

Identifiers

PMID41488596
PMCPMC7618554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.