Evidence map›Paper›PMID 41488588›Full record

ArticleInternational journal of breast cancer2026

Guestimating Molecular Subtyping of Breast Cancer by Ki67 in the Era of Artificial Intelligence.

Catherine E Connolly, Barbara Padberg Sgier, Regina Masser, Juliane Friemel, Quentin Simon, Annina Fasler, Eva Karamitopoulou, Marianne Tinguely

Abstract read
In one paragraph

Article in International journal of breast cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Catherine E ConnollyPathologie Institute Enge, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-6210-5161
Barbara Padberg SgierPathologie Institute Enge, Zürich, Switzerland.
Regina MasserPathologie Institute Enge, Zürich, Switzerland.
Juliane FriemelPathologie Institute Enge, Zürich, Switzerland.
Quentin SimonPathologie Institute Enge, Zürich, Switzerland.
Annina FaslerPathologie Institute Enge, Zürich, Switzerland.
Eva KaramitopoulouPathologie Institute Enge, Zürich, Switzerland.
Marianne TinguelyPathologie Institute Enge, Zürich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: This study aimed to compare the performance of immunohistochemistry (IHC)-based luminal subtyping of breast cancer against gene expression panels at our institute and to evaluate a CE-certified artificial intelligence (AI) Ki67 image analysis program for improving subtyping accuracy. Methods and Results: We retrospectively analysed IHC-based luminal subtyping in breast cancer biopsies diagnosed at our institute from 2019 to 2022 ( Conclusions: Our data provides a snapshot of the real-world allocation of multigene testing in early breast cancer, and supports other studies in highlighting the discrepancy between IHC-based and gene-based luminal subtyping. Ki67 evaluation remained consistent over time, and the use of AI for Ki67 scoring did not enhance the accuracy of IHC-based luminal subtyping.

Indexed as

artificial intelligencebreast cancerendopredictKi67luminal subtypingOncotype DX

Identifiers

PMID41488588
PMCPMC12759037

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.