ArticleClinical, cosmetic and investigational dermatology2025
Combination of Hyaluronic Acid and Polynucleotides Injection for the Treatment of Cheilitis Simplex.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cheilitis simplex is a prevalent form of cheilitis that is characterized by the presence of cracked lips, fissures, or desquamation, due to various etiologies. Utilization of "boosters" as a treatment for chapped lips has not been extensively researched. This case report aimed to describe the efficacy of lip booster injection comprising active ingredients of 1% hyaluronic acid (HA) and 1% polynucleotides (PN), with 0.3% lidocaine as anesthetic agent. A 30-year-old female patient presented with a chief complaint of dry and chapped lips that occasionally bleed. This condition had recently deteriorated, and the application of topical treatment had not yielded substantial improvement, which led to a state of distress for the patient. She was diagnosed with cheilitis simplex and was subsequently treated with a single subdermal injection of a combination of 1% HA, 1% PN, and 0.3% lidocaine. Lip hydration was increased gradually, as measured by tewameter, with peak rate of hydration (26.218 g/m
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