ArticleRSC advances2025
Rationally engineered PEGylated l-citrulline functionalized baicalein encapsulated HSA nanopolymer guided by molecular docking for tumor microenvironment responsive and redox modulated colon cancer therapy.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Colon cancer remains a major global health burden characterized by uncontrolled proliferation, oxidative stress, and poor responsiveness to conventional therapies, underscoring the need for biocompatible and targeted nanotherapeutic interventions. In this study, a novel pH-responsive human serum albumin-based nanocarrier, HSA-BA@PEG-LC NPs, was designed for the efficient and selective delivery of baicalein (BA) to colon cancer cells. Molecular docking analysis demonstrated strong binding affinities of BA with Hsp90 inhibitors and with human serum albumin (HSA), as well as a notable interaction between l-citrulline (LC) and the cationic amino acid transporter 1 (CAT-1), highlighting their potential roles in anticancer modulation. The engineered nanoparticles exhibited a uniform spherical morphology (232 nm), low polydispersity index (PDI < 0.3), and high colloidal stability (-27.21 mV). Spectroscopic analyses (FTIR and
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