Evidence map›Paper›PMID 41488519›Full record

ArticleRSC advances2025

Development of substituted 2-(4-(sulfonyl)piperazin-1-yl)quinazoline molecular hybrids as a new class of antimalarials.

Hari Madhav, Ashutosh Panda, Dipanwita Datta, Kashfa Shaheen, Abdur Rahman, Azhar Tariq Khan, Souvik Bhattacharjee, Dhiraj Kumar, Pawan Malhotra, Nasimul Hoda

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hari MadhavDrug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia New Delhi-110025 India nhoda@jmi.ac.in.ORCID https://orcid.org/0000-0003-4992-096X
Ashutosh PandaInternational Centre for Genetic Engineering and Biotechnology (ICGEB) New Delhi-110067 India pawanmal@gmail.com pawanm@icgeb.res.in.
Dipanwita DattaInternational Centre for Genetic Engineering and Biotechnology (ICGEB) New Delhi-110067 India pawanmal@gmail.com pawanm@icgeb.res.in.
Kashfa ShaheenDrug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia New Delhi-110025 India nhoda@jmi.ac.in.
Abdur RahmanSpecial Centre for Molecular Medicine, Jawaharlal Nehru University New Delhi-110067 India.
Azhar Tariq KhanDrug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia New Delhi-110025 India nhoda@jmi.ac.in.
Souvik BhattacharjeeSpecial Centre for Molecular Medicine, Jawaharlal Nehru University New Delhi-110067 India.
Dhiraj KumarInternational Centre for Genetic Engineering and Biotechnology (ICGEB) New Delhi-110067 India pawanmal@gmail.com pawanm@icgeb.res.in.
Pawan MalhotraInternational Centre for Genetic Engineering and Biotechnology (ICGEB) New Delhi-110067 India pawanmal@gmail.com pawanm@icgeb.res.in.
Nasimul HodaDrug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia New Delhi-110025 India nhoda@jmi.ac.in.ORCID https://orcid.org/0000-0001-9779-2056

Funding

Wellcome Trust
6 · The paper itself

Abstract

The rapid emergence of drug resistance makes malaria elimination a global challenge despite the prevalence of artemisinin-based combination therapies (ACTs), thus highlighting the urgent need for the development of new antimalarials with novel modes of action. The present study aimed to develop new quinazoline hybrid antimalarials using bioactive small building blocks. The antimalarial activity results revealed that most molecular hybrids have IC

Identifiers

PMID41488519
PMCPMC12757936

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.