ArticleMaterials today. Bio2026
Self-regulating neohesperidin/silk fibroin composite aerogel for enhanced wound healing via pH-responsive release.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Green synergistic non-thermal processing of Xinhui Chenpi: targeted fraction screening and mechanistic elucidation of antioxidant enhancement in Caenorhabditis elegans.Journal of the science of food and agriculture · 2026Article
- Cellulose and Its Derivatives-Based Skin Dressings: Design, Smart Advances and Applications.Pharmaceutics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effective wound healing and tissue regeneration are serious challenges in wound repair. Diseases or external stimuli that affect the body can generate excessive free radicals, which can trigger oxidative stress, inhibit wound healing, and lead to the formation of chronic wounds. Wound healing inhibition can be overcome by regulating the redox balance between reactive oxygen species (ROS) and antioxidants. Neohesperidin (Ne), a plant flavonoid compound with potent antioxidant properties, shows promise in mitigating oxidative stress and supporting wound healing. Here, we developed a novel aerogel dressing (MT-LCA + SF-Ne) by integrating silk fibroin (SF) and Ne into modified cellulose aerogels. The SF-mediated continuous delivery combined with the dual antioxidant/anti-inflammatory effects of Ne results in a sustained-release therapeutic system for wound microenvironment modulation. The aerogel was optimized by tuning its composition, SF concentration, and Ne loading, endowing it with suitable mechanical strength, thermal stability, and biocompatibility, while enabling pH-responsive Ne release aligned with wound healing dynamics. The aerogel disrupted the ROS-inflammation cascade and downregulated the M1/M2 macrophage ratio, thereby enhancing cell proliferation and migration, and demonstrating robust anti-inflammatory and antioxidant properties
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.