A novel biomimetic nanozyme orchestrates ulcerative colitis resolution by targeting KEAP1-NRF2-ARE pathway: Redox balance restoration, colonic barrier repair, immune homeostasis regulation.

Ping Gong, Yuqi Wang, Jia-He Qiu, Guanghui Li, Ke-Wei Chen, Zhuoya Li, Xi Wang, Liping Wang

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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Ping GongKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China.

Yuqi WangKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China.

Jia-He QiuKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China.

Guanghui LiHuazhong Agricultural University, Wuhan, Hubei, 430070, China.

Ke-Wei ChenLab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.

Zhuoya LiDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, China.

Xi WangDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130041, China.

Liping WangKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC) leads to systemic complications with excessive oxidative stress, colonic barrier damage, and inflammation. Deuterohemin-AlaHisThrValGluLys (DhHP-6) is the biomimetic nanozyme rationally designed to mimic the peroxidase activity of Microperoxidase-11. It exhibits potent antioxidant properties, which might emerge as a promising therapeutic candidate compound for UC. In this paper, we aimed to probe the therapeutic effects of DhHP-6 on UC and clarify the underlying molecular mechanisms. We employed dextran sulfate sodium-induced C57BL/6 J male mice for

Indexed as

DhHP-6InflammationMitochondriaNanozymeOxidative stressUlcerative colitis

Identifiers

PMID41488425

DOI10.1016/j.mtbio.2025.102627

PMCPMC12756036

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