Evidence map›Paper›PMID 41488419›Full record

ArticleClinical epidemiology2025

Validity of the Leading Causes of Death Classification for Premature Mortality in Inflammatory Bowel Disease: A Population-Based Comparison with ICD-10 Coding in Ontario, Canada.

Gemma Postill, M Ellen Kuenzig, Pablo A Olivera, Ijeoma Uchenna Itanyi, Vinyas Harish, Furong Tang, Emmalin Buajitti, Laura C Rosella, Eric I Benchimol

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gemma PostillInstitute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-6185-995X
M Ellen KuenzigSickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-3984-8426
Pablo A OliveraInstitute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Ijeoma Uchenna ItanyiDepartment of Public Health Sciences, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Vinyas HarishInstitute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Furong TangChild Health Evaluative Sciences, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.
Emmalin BuajittiICES, Toronto, ON, Canada.
Laura C RosellaInstitute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Eric I BenchimolInstitute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-8855-3598

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Studying patterns of death, particularly premature deaths (<75 years), provides insights to address health inequities among those living. Multiple coding systems for cause of death (COD) exist. The Leading Causes of Death (LCD) scheme is designed for identifying priority COD for interventions in global populations. The extent to which such classification is effective for identifying priority causes of premature mortality among subpopulations with chronic health conditions, such as inflammatory bowel disease (IBD), is unknown. Objective: To evaluate the usability of the LCD for characterizing premature mortality among those with IBD. Methods: We conducted a population-based matched case control study of persons with IBD who died between 2010 and 2018 using linked health administrative data from Ontario, Canada. Individuals with IBD were matched with five decedents without IBD based on sex and years of birth and death. We compared COD for premature and overall mortality using two classification structures: the LCD scheme and the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10) chapters. Results: Among 7,919 decedents with IBD (39,414 matched controls), 47% died prematurely. With the LCD framework, COD differences for premature mortality were not detectable as 29% were allocated to the residual category (Standardized differences [SD]: 18%). Most residual deaths were due to neoplasms (34%) or diseases of the gastrointestinal system (32%). Using ICD-10 chapters, premature deaths were more commonly due to diseases of the digestive system than for matched controls (13% vs 5%, SD: 31%). Discussion: The LCD coding scheme provides more granular COD details compared to the ICD-10 chapters. However, a larger proportion of deaths among people with IBD were allocated to the residual category, limiting its utility for enabling healthcare systems to identify priority targets to reduce premature mortality. Further work to develop and validate a framework for premature COD classification in populations with IBD is needed.

Indexed as

Crohn’s diseasedeath categorizationdiagnostic codeshealth administrative datapremature deathulcerative colitis

Identifiers

PMID41488419
PMCPMC12756957

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.