ArticleInternational journal of particle therapy2026
Proton-Based Re-Irradiation of Locally Recurrent Pediatric Brain Tumors in Close Proximity to the Brainstem.
Article in International journal of particle therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Advancing Particle Therapy to Improve Cancer Care: Report on "2nd World Forum on Particle Therapy".International journal of particle therapy · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Local recurrence of aggressive, pediatric brain tumors remains a challenge. We offered full-course re-irradiation with proton therapy (PT) to children with local failures in proximity to the brainstem. Patients and Methods: Eleven children (7 male, 4 female) underwent fractionated re-irradiation using pencil beam-based PT for local recurrence following maximum prior multidisciplinary treatment for ependymoma ( Results: At median follow-up of 42.5 months (range 7-63), 9 /11 children (82%) achieved local control. Actuarial 2- and 3-year local control and overall survival rates were 89% and 76%, and 82% and 73%, respectively.Strategies of balancing target dose with OAR considerations resulted in a median cumulative brainstem surface dose (D Conclusion: Selective re-irradiation with pencil beam-based proton radiotherapy, using specifically modified treatment planning approaches, can be effective and safe, even in cases with tumor abutting the brainstem.
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