ArticleiScience2025
Effects of psychosocial stress on myocardial injury by modulating endoplasmic reticulum stress-induced autophagy and inflammation.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychosocial stress, a known trigger for depression, activates the sympathetic nervous system and serves as an independent risk factor for cardiovascular disease (CVD). However, its underlying mechanisms remain unclear. Endoplasmic reticulum stress (ERS), a protective response to stress, is linked to mental disorders. In depression patients, levels of NOD-like receptor thermal protein domain-associated protein 3 (NLRP3), nuclear factor kappa-B (NF-κB), and interleukin-1β (IL-1) were elevated, while HRV parameters were reduced. Social defeat stress was found to activate autonomic neural activity, subsequently leading to myocardial injury through ERS modulation. Dopamine (DA), 5-hydroxytryptamine (5-HT), and corticosterone (CORT) levels were measured by ELISA. The number and morphology of amygdala neurons were evaluated via Nissl and TUNEL staining. ERS-induced autophagy and inflammation were assessed using western blot and immunofluorescence staining. This study links ERS to myocardial injury, suggesting ERS modulation could represent a potential therapeutic strategy for stress-induced myocardial injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.