Evidence map›Paper›PMID 41488362›Full record

ArticleiScience2025

Pediatric critical illness endotypes reveal distinct outcomes and immune pathways shared across cause of illness.

Michael J Carter, Joshua Hageman, Yael Feinstein, Jethro Herberg, Dominic Habgood-Coote, Victoria Wright, Samuel Nichols, Nazima Pathan, Naomi Edmonds, Philip D Cowie and 8 more

Abstract read
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Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Michael J CarterDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Joshua HagemanDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Yael FeinsteinDepartment of Paediatrics, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv-Yafo, Israel.
Jethro HerbergSection of Paediatric Infection, Faculty of Medicine, Imperial College London, London, UK.
Dominic Habgood-CooteSection of Paediatric Infection, Faculty of Medicine, Imperial College London, London, UK.
Victoria WrightSection of Paediatric Infection, Faculty of Medicine, Imperial College London, London, UK.
Samuel NicholsSection of Paediatric Infection, Faculty of Medicine, Imperial College London, London, UK.
Nazima PathanDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
Naomi EdmondsPaediatric Intensive Care Unit, Royal London Hospital, Barts Health NHS Foundation Trust, London, UK.
Philip D CowiePaediatric Intensive Care Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Katie BurnhamWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.
Alexander MentzerCentre for Human Genetics, University of Oxford, Oxford, UK.
Julian KnightCentre for Human Genetics, University of Oxford, Oxford, UK.
Michael LevinSection of Paediatric Infection, Faculty of Medicine, Imperial College London, London, UK.
Myrsini KaforouSection of Paediatric Infection, Faculty of Medicine, Imperial College London, London, UK.
Simon NadelPaediatric Intensive Care Unit, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.
Mark J PetersUCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Padmanabhan RamnarayanDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Characterization of shared patterns of immune responses in critical illnesses, known as "endotypes," may have therapeutic significance. Using unsupervised k-means clustering of genome-wide gene expression profiling, we derived, validated, and assigned endotype membership in 382 children with diverse critical illnesses recruited to the BASIC study. We identified two robust endotypes, BASIC endotype 1 (122, 31.9%, children) and BASIC endotype 2 (260, 68.1%, children), present in children with diverse illnesses and age groups. BASIC endotype 1 membership was associated with 4.1 days of increased duration of mechanical ventilation and a non-significant association with mortality. BASIC endotype 1 membership was associated with higher proportions of naive and resting memory CD4 T cells, lower proportions of neutrophils, and reduced expression of gene sets associated with tumor necrosis factor alpha (TNF-α), interferon-γ, interferon-α, and interleukin-6/JAK/STAT pathways in comparison with BASIC endotype 2. These BASIC endotypes may enable stratified trials of treatment for immune dysfunction.

Indexed as

Clinical geneticsImmunologyPediatrics

Identifiers

PMID41488362
PMCPMC12756572

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