Evidence map›Paper›PMID 41488359›Full record

ArticleiScience2025

Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception.

Anushka C Wickramaratne, Emil Sjulstok Rasmussen, Yogarany Chelliah, Fabian Schuhmann, Ilia A Solov'yov, Henrik Mouritsen, Carla B Green, Brian D Zoltowski, Joseph S Takahashi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Integrated Analysis ofBiomolecules · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anushka C WickramaratneLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Emil Sjulstok RasmussenDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.
Yogarany ChelliahDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.
Fabian SchuhmannNiels Bohr International Academy, Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, 2100 Copenhagen, Denmark.
Ilia A Solov'yovInstitute of Physics, Carl von Ossietzky Universität Oldenburg, Carl-von-Ossietzky Str. 9-11, 26129 Oldenburg, Germany.
Henrik MouritsenResearch Centre for Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany.
Carla B GreenDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.
Brian D ZoltowskiDepartment of Chemistry, Southern Methodist University, Dallas, TX 75275, USA.
Joseph S TakahashiDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Molecular mechanisms of mammalian circadian clock function - Renewal - 1R35GM127122 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Carla B. Green · 2018 to 2026
$6.0M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Structural Flexibility Mediates Circadian Adaptation in Diverse OrganismsR15GM109282 · NIGMS · SOUTHERN METHODIST UNIVERSITY · PI ZOLTOWSKI, BRIAN DAVID · 2014 to 2021
$1.2M
NIDDK NIH HHS P30 DK127984NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R15 GM109282NIGMS NIH HHS R35 GM127122NIH HHS S10 OD021527
6 · The paper itself

Abstract

Cryptochromes (CRYs) play critical roles in regulating diverse physiological functions, including circadian rhythms and neuronal firing in light-dependent or -independent fashions. Structural studies of CRYs have highlighted common features, such as the photolyase homology region (PHR), but they also reveal key differences, particularly in the binding of the flavin adenine dinucleotide (FAD) cofactor, leading to a long-standing debate, namely, whether Type I CRYs can function as FAD-dependent photosensors. This study solves the first crystal structure of a Type II CRY from a migratory songbird, namely, the European robin (

Indexed as

BiochemistryEvolutionary biologyEvolutionary ecologyZoology

Identifiers

PMID41488359
PMCPMC12757563

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.