Evidence map›Paper›PMID 41488339›Full record

ArticleFrontiers in antibiotics2025

Human-environmental overlap of resistant Enterobacterales: genomic evidence linking coastal waters and community carriage of antimicrobial resistance in a low- and middle-income setting.

Appiah-Korang Labi, Noah Obeng-Nkrumah, Abigail Sarpong, Lady Asantewah Boamah Adomako, Christian Owusu-Nyantakyi, Rachel Ama Adadziwa Akorful, Mary-Magdalene Osei, Beverly Egyir, Japheth Awuletey Opintan

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Article in Frontiers in antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Appiah-Korang Labi *Department of Medical Microbiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Noah Obeng-Nkrumah *Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.
Abigail SarpongDepartment of Medical Microbiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Lady Asantewah Boamah AdomakoEnvironmental Biology Biotechnology and Health Division, Council for Scientific and Industrial Research, Water Research Institute, Accra, Ghana.
Christian Owusu-NyantakyiBacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Rachel Ama Adadziwa AkorfulDepartment of Medical Microbiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Mary-Magdalene OseiDepartment of Medical Microbiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.
Beverly EgyirBacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Japheth Awuletey OpintanDepartment of Medical Microbiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Coastal waters contaminated by antimicrobial resistant hotspots may serve as reservoirs for third-generation cephalosporin resistant Enterobacterales (3GCR-E), extended-spectrum β-lactamase (ESBL)-producers, and carbapenem-resistant Enterobacterales (CRE), but their role in driving human carriage remains poorly understood. Aim: We investigated intestinal carriage of 3GCR-E, ESBL-producers, and CRE in coastal and inland communities in Accra, Ghana, and examined the genomic overlap between human and wastewater-derived CRE isolates. Methods: A comparative cross-sectional study was conducted from August 2023 to June 2024 with 800 participants (400 from coastal and 400 from inland communities). We cultured fecal samples from participants and water samples from lagoons and shorelines for 3GCR-E, ESBL-producers, and CRE. The CRE isolates from both human and wastewater were whole genome sequenced for comparison. Results: Overall, 53.6% (n=429/800) of participants carried 3GCR-E, with 43.6% being ESBL-producers and 1.5% being CRE, the latter restricted only to coastal residents. In the pooled analysis, inland residence was independently associated with reduced odds of 3GCR-E carriage (aOR 0.64, 95% CI 0.48-0.85; Conclusions: Our findings indicate a shared resistance gene pool between human and environmental sources, characterized by bidirectional CRE exchange but dominated by an environment-to-human transmission pathway. This underscores the urgent need for effective wastewater treatment and improved sanitation practices to reduce human exposure and curb the spread of antibiotic resistance.

Indexed as

antimicrobioal resistance (AMR)carbapenem-resistant EnterobacteralesGhanaintestinal carriageone healthwastewater

Identifiers

PMID41488339
PMCPMC12756717

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