Evidence map›Paper›PMID 41488312›Full record

ArticleFrontiers in microbiology2025

Translating

Femke P M Hoevenaars, Torsten P M Scheithauer, Boukje C Eveleens Maarse, Isabela M de Oliveira, Ines Warnke, Wilbert Sybesma, Matthijs Moerland, Tim J van den Broek, Frank H J Schuren

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Femke P M Hoevenaars *Department of Microbiology & Systems Biology, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, Netherlands.
Torsten P M Scheithauer *Department of Microbiology & Systems Biology, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, Netherlands.
Boukje C Eveleens MaarseCentre for Human Drug Research, Leiden, Netherlands.
Isabela M de OliveiraDepartment of Microbiology & Systems Biology, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, Netherlands.
Ines WarnkeDSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
Wilbert SybesmaMicrobiome Solutions, Niederhünigen, Switzerland.
Matthijs MoerlandCentre for Human Drug Research, Leiden, Netherlands.
Tim J van den BroekDepartment of Microbiology & Systems Biology, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, Netherlands.
Frank H J SchurenDepartment of Microbiology & Systems Biology, Netherlands Organisation for Applied Scientific Research (TNO), Leiden, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Large interindividual variation in human gut microbiota composition and its response to interventions limits the development of novel microbiota-targeted supplements. Methods: Here, we investigated whether in vitro microbiota modulation by a dietary fiber mixture is translatable to in vivo microbiota outcomes. A 12-week double blind, randomized, placebo-controlled, crossover study with a dietary fiber mixture of acacia gum (AG) and carrot powder was performed in healthy volunteers ( Results: A significant effect on microbiota composition was shown in vivo, although with strong individual variation. The fiber intervention was mimicked in vitro by exposing each individuals' baseline microbiota to the same dietary fiber as used for the 12-weeks in vivo intervention. A significant correlation was shown between the in vitro and human fecal microbiota composition after 8- and 12-weeks intervention ( Discussion: These results demonstrate that in vitro models may enable pre-study selection of donors whose microbiotas respond to a specific intervention.

Indexed as

dietary fibersgastrointestinal healthgut microbiotain vitro systemsin vivo translation

Identifiers

PMID41488312
PMCPMC12756460

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.