ArticleWorld journal of oncology2026
High CDCP1 Expression Reflects Immune and Stromal Remodeling and Oncogenic Signaling in Pancreatic Ductal Adenocarcinoma.
Article in World journal of oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: CUB domain-containing protein 1 (CDCP1) is implicated in pancreatic ductal adenocarcinoma (PDAC) prognosis, but its relationship to the tumor microenvironment (TME) and oncogenic signaling remains incompletely defined. We hypothesized that CDCP1 expression is associated with hallmark cancer signaling pathways and transcriptionally inferred TME remodeling in PDAC. Methods: We analyzed transcriptomic and clinical data from 214 PDAC cases (The Cancer Genome Atlas (TCGA), n = 145; GSE62452, n = 69). Patients were stratified into high CDCP1 and low CDCP1 groups based on the top tertile of expression. Immune and stromal components of the TME were quantified using the xCell algorithm. Gene Set Enrichment Analysis (GSEA) with Hallmark gene sets was used for pathway enrichment. Results: High CDCP1 expression was significantly associated with reduced infiltration of CD8 Conclusion: CDCP1 defines a transcriptionally distinct PDAC subtype characterized by immune evasion, stromal depletion, and genomic instability. These findings highlight CDCP1 as a potential therapeutic target and biomarker reflecting interplay between oncogenic signaling and the TME.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.