Evidence map›Paper›PMID 41488247›Full record

ReviewTurkish journal of medical sciences2025

Endocrine-disrupting chemicals and thyroid cancer.

Özge Baş Aksu, Mustafa Şahin

Abstract readReview
In one paragraph

Review in Turkish journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Özge Baş AksuDepartment of Endocrinology and Metabolism, Faculty of Medicine, Ankara University, Ankara, Turkiye.ORCID https://orcid.org/0000-0003-3124-9477
Mustafa ŞahinDepartment of Endocrinology and Metabolism, Faculty of Medicine, Ankara University, Ankara, Turkiye.ORCID https://orcid.org/0000-0002-4718-0083

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental endocrine-disrupting chemicals (EDCs) have emerged as a critical global health concern because of their role in various diseases, including thyroid cancer. Defined as exogenous substances that disrupt endocrine system functions, EDCs can affect multiple generations through mechanisms such as hormone receptor modulation, altered hormone synthesis, and epigenetic modifications. The increasing global incidence of thyroid cancer has heightened interest in environmental factors, with EDC exposure recognized as a significant contributor. Compounds such as heavy metals, persistent organic pollutants, per- and polyfluoroalkyl substances, and bisphenol A play crucial roles in disrupting thyroid homeostasis. Emerging evidence underscores the synergistic effects of multiple EDC exposures, further amplifying cancer risk. This review explores the relationship between EDC exposure and thyroid carcinogenesis, focusing on key chemical compounds and their mechanisms of action. Understanding these links is essential for guiding public health policies and shaping future research aimed at preventing and improving the management of this malignancy.

Indexed as

Endocrine DisruptorsEnvironmental ExposureEnvironmental PollutantsThyroid NeoplasmsHumansEndocrine DisruptorsEnvironmental Pollutantsendocrine-disrupting chemicalspollutionpublic healthThyroid cancer

Identifiers

PMID41488247
PMCPMC12758927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.