Evidence map›Paper›PMID 41488194›Full record

ArticleRheumatology advances in practice2026

Temporal trends in lupus pregnancy over four decades in a referral centre: pregnancy planning and hydroxychloroquine use are associated with improved outcomes.

Dionysia Mandilara, Spyridon Katechis, Sofia Flouda, Katerina Chavatza, Konstantinos Drougkas, Dimitrios Katsifis-Nezis, Dimitrios T Boumpas, Antonis Fanouriakis

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Article in Rheumatology advances in practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Dionysia MandilaraRheumatology and Clinical Immunology Unit, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Spyridon KatechisRheumatology and Clinical Immunology Unit, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-8575-5183
Sofia FloudaRheumatology and Clinical Immunology Unit, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Katerina ChavatzaRheumatology and Clinical Immunology Unit, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos DrougkasRheumatology and Clinical Immunology Unit, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0009-0003-0143-6404
Dimitrios Katsifis-NezisRheumatology and Clinical Immunology Unit, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios T BoumpasRheumatology and Clinical Immunology Unit, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Antonis FanouriakisRheumatology and Clinical Immunology Unit, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0003-2696-031X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate temporal trends in pregnancy management and outcomes in women with SLE and explore the impact of pregnancy planning on maternal and foetal complications. Methods: We conducted a retrospective study including women with SLE with one or more pregnancies after diagnosis or diagnosed during pregnancy. Data were collected through questionnaires and medical records. To assess temporal trends, the study period (1985-2024) was divided into five intervals with similar pregnancy and patient distribution. Using generalized estimating equations, we identified risk factors for adverse pregnancy outcomes and evaluated temporal trends in pregnancy characteristics. Results: We recorded 109 pregnancies from 65 women; 70.6% resulted in live births. Planned pregnancies were associated with a lower flare risk [odds ratio (OR) 0.31 (95% CI 0.11, 0.89)] and a higher likelihood of live birth [OR 3.31 (95% CI 1.41, 7.8)]. HCQ use during pregnancy was independently associated with a reduced flare risk [OR 0.26 (95% CI 0.08, 0.8)]. Pregnancies before 2005 were less often planned [OR 0.10 (95% CI 0.03, 0.4)], while HCQ use during pregnancy increased over time [OR 0.56 (95% CI 0.34, 0.95), for the period 1985-2005 Conclusion: Pregnancy management and outcomes improved over time in SLE; planned pregnancy and HCQ use were associated with favourable results.

Indexed as

hydroxychloroquineplanned pregnancypreconception counsellingsystemic lupus erythematosustemporal trends

Identifiers

PMID41488194
PMCPMC12758124

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