Evidence map›Paper›PMID 41488190›Full record

ArticleRheumatology advances in practice2026

Patterns of steroid use in patients with established rheumatoid arthritis commencing treatment with biologic or targeted synthetic DMARDs.

Michael Stadler, Shae Bindra, Annie Cheung, Chuan Fu Yap, James Bluett, Darren Plant, Nisha Nair, Kimme Hyrich, Ann Morgan, Anthony G Wilson and 2 more

Abstract read
In one paragraph

Article in Rheumatology advances in practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael StadlerCentre for Genetics and Genomics Versus Arthritis, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0003-3689-4256
Shae BindraCentre for Genetics and Genomics Versus Arthritis, University of Manchester, Manchester, UK.
Annie CheungNIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, UK.
Chuan Fu YapCentre for Genetics and Genomics Versus Arthritis, University of Manchester, Manchester, UK.
James BluettCentre for Genetics and Genomics Versus Arthritis, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0001-5062-5779
Darren PlantCentre for Genetics and Genomics Versus Arthritis, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0003-1395-9344
Nisha NairCentre for Genetics and Genomics Versus Arthritis, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0001-9829-792X
Kimme HyrichNIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, UK.ORCID https://orcid.org/0000-0001-8242-9262
Ann MorganSchool of Medicine, University of Leeds, Leeds, UK.ORCID https://orcid.org/0000-0003-1109-624X
Anthony G WilsonUCD School of Medicine and Medical Science, Conway Institute, University College, Dublin, Ireland.
John D IsaacsTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Anne BartonCentre for Genetics and Genomics Versus Arthritis, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0003-3316-2527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To investigate the clinical use of steroids in established RA. Methods: A cohort of RA patients commencing treatment with biologic or targeted synthetic (b/ts) DMARDs was followed prospectively, with clinical data recorded pre-baseline and at the 3, 6 and 12-month follow-up. Patients were included in this analysis if they had completed the first year of follow-up and had data on steroid use available for at least one follow-up. The proportions of patients receiving steroids at different timepoints were compared and further differentiated between continued (receiving steroids at two consecutive timepoints) and newly started treatment. Lastly, mixed linear effect models were used to assess the relationship between clinical factors and steroid use. Results: The cohort ( Conclusion: Despite the introduction of b/tsDMARDs, steroid use in this cohort continued over the first year of follow-up, particularly in patients with more severe RA. Together with previous data, this further highlights the need for future research and trials to better understand the right course of steroid administration to maximize efficacy and limit adverse side effects.

Indexed as

biologicsglucocorticoidsrheumatoid arthritis

Identifiers

PMID41488190
PMCPMC12758120

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.