Evidence map›Paper›PMID 41488125›Full record

ArticleACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine2025

Fair CCA for Fair Representation Learning: An ADNI Study.

Bojian Hou, Zhanliang Wang, Zhuoping Zhou, Boning Tong, Zexuan Wang, Jingxuan Bao, Duy Duong-Tran, Qi Long, Li Shen

Abstract read
In one paragraph

Article in ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bojian HouUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Zhanliang WangUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Zhuoping ZhouUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Boning TongUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Zexuan WangUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jingxuan BaoUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Duy Duong-TranUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Qi LongUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Li ShenUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Laurel A Beckett · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Minerva Maria Carrasquillo, NILUFER ERTEKIN-TANER · 2023 to 2026
$42.0M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Artificial Intelligence Strategies for Alzheimer's Disease ResearchU01AG066833 · NIA · CEDARS-SINAI MEDICAL CENTER · PI MOORE, JASON H., RITCHIE, MARYLYN D · 2022 to 2025
$6.7M
Translational big data analytic approaches to advance drug repurposing for Alzheimer's diseaseR01AG071470 · NIA · UNIVERSITY OF PENNSYLVANIA · PI KIM, DOKYOON, NING, XIA · 2021 to 2025
$3.8M
Advancing Analysis of Multi-omics Data in Alzheimer's Disease ResearchRF1AG063481 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LONG, QI · 2019 to 2020
$3.8M
Informatics Algorithms for Genomic Analysis of Brain Imaging DataR01LM013463 · NLM · UNIVERSITY OF PENNSYLVANIA · PI MOORE, JASON H., SAYKIN, ANDREW J · 2020 to 2023
$1.4M
NIA NIH HHS R01 AG071470NIA NIH HHS RF1 AG063481NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG066833NIA NIH HHS U01 AG068057NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG074879NLM NIH HHS R01 LM013463
6 · The paper itself

Abstract

Canonical correlation analysis (CCA) is a technique for finding correlations between different data modalities and learning low-dimensional representations. As fairness becomes crucial in machine learning, fair CCA has gained attention. However, previous approaches often overlook the impact on downstream classification tasks, limiting applicability. We propose a novel fair CCA method for fair representation learning, ensuring the projected features are independent of sensitive attributes, thus enhancing fairness without compromising accuracy. We validate our method on synthetic data and real-world data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), demonstrating its ability to maintain high correlation analysis performance while improving fairness in classification tasks. Our work enables fair machine learning in neuroimaging studies where unbiased analysis is essential. Code is available in https://github.com/ZhanliangAaronWang/FR-CCA-ADNI.

Indexed as

Alzheimer’s DiseaseCCAFairnessRepresentation Learning

Identifiers

PMID41488125
PMCPMC12758915

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.