Evidence map›Paper›PMID 41488122›Full record

ArticleJournal of asthma and allergy2025

Alternaria Sensitization and Allergy in Children and Adolescents: A Retrospective Diagnostic Study.

Gözde Kabadayi, Jordis Trischler, Martin Hutter, Stefan Zielen, Katharina Blumchen, Johannes Schulze

Abstract read
In one paragraph

Article in Journal of asthma and allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [A Randomized Controlled Clinical Trial of Acupuncture at the Sphenopalatine Ganglion for the Treatment of Allergic Rhinitis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gözde KabadayiDepartment of Pediatrics University Hospital, Division of Pneumology, Allergology, Infectious Diseases and Gastroenterology, Goethe University, Frankfurt, Germany.
Jordis TrischlerDepartment of Pediatrics University Hospital, Division of Pneumology, Allergology, Infectious Diseases and Gastroenterology, Goethe University, Frankfurt, Germany.
Martin HutterDepartment of Pediatrics University Hospital, Division of Pneumology, Allergology, Infectious Diseases and Gastroenterology, Goethe University, Frankfurt, Germany.
Stefan ZielenDepartment of Pediatrics University Hospital, Division of Pneumology, Allergology, Infectious Diseases and Gastroenterology, Goethe University, Frankfurt, Germany.
Katharina BlumchenDepartment of Pediatrics University Hospital, Division of Pneumology, Allergology, Infectious Diseases and Gastroenterology, Goethe University, Frankfurt, Germany.
Johannes SchulzeDepartment of Pediatrics University Hospital, Division of Pneumology, Allergology, Infectious Diseases and Gastroenterology, Goethe University, Frankfurt, Germany.ORCID 0009-0002-3022-3849

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Patients and Methods: A retrospective analysis of electronic medical records to 2011-2021 was performed on symptoms, SPT-AA, AA-IgE, lung function, asthma therapy and bronchial provocation using Results: 149 children and adolescents (5-18 years) with Alternaria allergy were investigated. Between June and September, 86 Alternaria-sensitized patients had asthmatic symptoms and 113 had nasal symptoms (often outdoors or with mold exposure). SPT-AA and AA-IgE levels did not differ between the symptomatic and asymptomatic patients (SPT-AA, p= 0.23). A weak correlation was observed between the diagnostic tests in 49 patients with bronchial and/or nasal symptoms (r= 0.36, p= 0.01). Nineteen patients received provocation, 16 showed an early asthmatic response and 14 a late asthmatic response. Patients with BP-AA had a medium SPT-AA ≥7 mm or AA-IgE ≥16.8 kU/L. Both tests significantly correlate with PD20-AA (r= -0,49, p< 0.01 and r= 0.26, p< 0.01, respectively). Conclusion: The Diagnosis of Alternaria allergy is still a challenge. The weak to moderate correlation between SPT-AA and AA-IgE seems to be allergen-specific. Typical medical history is a key diagnostic criterion. Allergy profiles and climate may play a role in the manifestation of symptoms. BP-AA help to establish threshold values for SPT-AA and AA-IgE. In unclear cases, nasal or bronchial provocation should be performed before immunotherapy.

Indexed as

allergic asthmaallergic rhinitisbronchial allergen provocationserum-specific IgEskin prick test

Identifiers

PMID41488122
PMCPMC12764227

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.