ArticleFrontiers in medicine2025
Comparative study of 5% permethrin, 10% neem leaf extract, and 10% brotowali stem extract for scabies treatment.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
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Abstract
Background: Scabies, a contagious skin infestation caused by Objective: This study compared the efficacy, safety, and quality-of-life impact of 5% permethrin lotion with 10% neem ( Methods: A true experimental pre- and post-test controlled design was conducted involving 61 male students diagnosed with scabies. Participants were randomized into three treatment groups: 5% permethrin, 10% neem leaf extract, or 10% brotowali stem extract. The study was carried out from April to May 2021. Clinical improvement was assessed using lesion counts based on the Physician Global Assessment (PGA), while quality of life was evaluated using the Dermatology Life Quality Index (DLQI). Adverse effects were documented, and bivariate analyses were performed. Results: All three treatments significantly reduced lesion counts ( Limitations: Treatment adherence and exact application duration could not be fully controlled, and the possibility of reinfestation could not be excluded. Conclusion: Neem leaf extract and brotowali stem extract lotions are as effective and safe as permethrin in treating scabies and improving patient quality of life. Both offer promising, affordable alternatives for scabies management in resource-limited settings.
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