ArticleFrontiers in medicine2025
Precision approach to diabetic peripheral neuropathy: modified nerve decompression surgery and MNGF treatment.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Diabetic peripheral neuropathy (DPN) is a common and debilitating complication of diabetes, often resulting in pain, sensory loss, and lower limb ulcers. While traditional nerve decompression (ND) surgery can alleviate symptoms, it is associated with several limitations, including excessive surgical trauma, postoperative fibrosis, and limited efficacy in advanced cases. To address these challenges, this study aimed to precisely target anatomical sites of peripheral nerve compression identified through cadaveric dissection, perform selective decompression to minimize nerve injury, and investigate the therapeutic potential of combining modified ND with murine nerve growth factor (MNGF) to enhance clinical outcomes. Methods: In this assessor-blinded, three-arm exploratory randomized controlled trial, 42 patients with confirmed lower limb DPN were randomly assigned to one of three groups: traditional ND ( Results: All groups showed significant improvements in MNCV, TCSS, VAS, 2-PD, and sensory function after treatment ( Conclusion: Modified ND surgery, particularly when combined with MNGF administration, may offer a safe and minimally invasive treatment option for lower-limb DPN. Further validation in larger, multicenter trials is warranted.
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