ArticleFrontiers in medicine2025
A pilot study of cervicovaginal microbiome patterns associated with embryo implantation outcomes in endometriosis-associated infertility.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The cervicovaginal microbiome-spanning from the vagina to endometrium-remains undercharacterized in endometriosis-associated infertility. Objective: To determine whether combined vaginal and cervical microbial profiles predict frozen embryo transfer (FET) outcomes. Methods: In 22 endometriosis patients undergoing FET, paired vaginal and cervical samples were collected on transfer day. 16S rDNA sequencing quantified microbial composition; alpha/beta diversity, PCoA, LEfSe, and PICRUSt analyses identified taxonomic and functional signatures linked to implantation success. Conduct a differential analysis of microorganisms in different body parts through DMI. Results: Microbial profiles associated with successful pregnancies featured a higher relative abundance of Conclusions: Our pilot findings suggest that a continuous cervicovaginal microbial ecosystem presents distinct taxonomic and functional patterns associated with FET success in endometriosis. Specifically, cervical microbiota profiling emerges as a promising, minimally invasive approach worthy of further investigation to potentially personalize ART strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.