ArticleFrontiers in bioengineering and biotechnology2025
Enhancing radial strength and expansion uniformity of iron-based vascular scaffolds: a numerical and experimental investigation on topological optimization.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Topology-Driven Mechanical Tuning of FDM-Printed TPU Tubular Lattices with Auxetic Architectures.Micromachines · 2026Article
- Advances in Functional Vascular Stents for Cardiovascular Therapy with Drug Delivery and Computational Design.Pharmaceutics · 2026Review
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Authors and funding
7 authors.
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Abstract
Introduction: Thin-walled iron-based bioresorbable scaffolds have garnered significant research interest due to their exceptional mechanical properties and favorable biocompatibility. However, current thin-walled iron-based bioresorbable scaffold designs exhibit non-uniform expansion, leading to coating cracking, malapposition, postoperative in-stent restenosis (ISR), and localized pitting corrosion that compromises mechanical integrity. Methods: This study proposed a dual-factor optimization strategy prioritizing expansion homogeneity through finite element analysis and experimental validation. We systematically modulated the strut width and thickness, as well as the crown radial width in nitrided iron scaffolds, evaluating their mechanical and expansion performance. Results: It showed that the optimized (OPT) scaffold maintained comparable radial recoil and foreshortening to the original design while demonstrating significant reductions in maximum principal strain (19.2%) and equivalent plastic strain of expand (19.0%). Discussion:
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