ArticleCancer diagnosis & prognosis
C-reactive Protein-to-Albumin Ratio as a Superior Inflammatory Marker in Resected Biliary Tract Cancer: Development of a Prognostic Nomogram Complementary to TNM Staging.
Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- 30-day mortality prediction in acute upper gastrointestinal bleeding: Incremental value of the prognostic nutritional index with ABC and Rockall scores.Biomolecules & biomedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Aim: Consensus on the most informative inflammatory marker for prognosis in biliary tract cancer (BTC) is lacking. The aim of this study was to comprehensively evaluate preoperative inflammatory indices and develop a prognostic nomogram complementary to TNM staging. Patients and Methods: A total of 247 patients with resected BTC were retrospectively analyzed. Eight inflammatory indices, including prognostic nutritional index (PNI) and C-reactive protein-to-albumin ratio (CAR), were assessed alongside non-TNM clinicopathological variables. Least absolute shrinkage and selection operator (LASSO) regression identified overall survival-associated variables for multivariable Cox regression and nomogram construction. Model performance was evaluated using Kaplan-Meier analysis, concordance (C-) index, time-dependent area under the curve (tdAUC), decision curve analysis (DCA), and calibration plots, with bootstrap validation. Results: LASSO selected PNI and CAR; CAR remained independently significant. The nomogram incorporated CAR and five clinicopathological factors: body mass index ≥25 kg/m2, carbohydrate antigen 19-9 >37 U/ml, moderate/poor differentiation, perineural invasion, and residual tumor status. Patients were stratified by nomogram score into four risk groups showing distinct survival differences. Notably, 50.6% of TNM Stage I-II were reclassified as higher risk, 16.1% of Stage III-IV as lower risk. The nomogram achieved C-index 0.722 Conclusion: CAR demonstrated superiority over other inflammatory indices in resected BTC. This CAR-based nomogram complements TNM staging, offering enhanced prognostic stratification for patients with heterogeneous outcomes within the same anatomical stage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.