Evidence map›Paper›PMID 41487918›Full record

ReviewCancer diagnosis & prognosis

Prognostic Significance of Lymphatic Vessel Invasion and Density in Colorectal Carcinoma: A Systematic Review and Meta-analysis.

Dimitrios N Varvarousis, Aikaterini A Marini, Georgios Ntritsos, Kalliopi Iliou, Theocharis Chatzoglou, Alexandra Barbouti, Panagiotis V Kitsoulis, Panagiotis E Kanavaros

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dimitrios N VarvarousisDepartment of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece.
Aikaterini A MariniDepartment of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece.
Georgios NtritsosDepartment of Economics, University of Ioannina, University Campus, Ioannina, Greece.
Kalliopi IliouDepartment of Occupational Therapy, School of Health Sciences, University of Western Macedonia,Ptolemaida, Greece.
Theocharis ChatzoglouDepartment of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece.
Alexandra BarboutiDepartment of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece.
Panagiotis V KitsoulisDepartment of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece.
Panagiotis E KanavarosDepartment of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aim: This systematic review and meta-analysis evaluated the relationship between lymphatic vessel invasion (LVI) and lymphatic vessel density (LVD) - with specific focus on distinguishing peritumoral from intratumoral LVD, assessed by immunohistochemistry - and survival outcomes in patients with colorectal carcinoma (CRC). Materials and Methods: Following Cochrane Handbook and PRISMA guidelines, we included original studies evaluating tumor LVD and/or LVI in colorectal cancer using immunohistochemistry and reporting hazard ratios for overall survival (OS) and/or disease/recurrence-free survival (DFS). Data from MEDLINE, Cochrane Library, and PubMed (past 25 years) were extracted, analyzed with Stata, and assessed for heterogeneity and publication bias. Results: The principal results of the present study were the statistically significant correlations between a) LVI and reduced OS ( Conclusion: LVI and LVD parameters (peritumoral, intratumoral, total), evaluated using immunohistochemistry, may provide valuable information with respect to the prognosis of patients with CRC.

Indexed as

Colorectal carcinomasdisease-free survivallymphatic vessel densitylymphatic vessel invasionmeta-analysisoverall survivalreview

Identifiers

PMID41487918
PMCPMC12758676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.