Evidence map›Paper›PMID 41487858›Full record

ArticleCureus2025

An Uncommon Case of Lactational Hypercalcemia With Diagnostic and Therapeutic Challenges.

Yaline Sathiyaseelan, Ananth Srinivashan, Guganesan Vitush

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yaline SathiyaseelanDepartment of Internal Medicine, St. Mary's Hospital, Isle of Wight National Health Service (NHS) Trust, Newport, GBR.
Ananth SrinivashanDepartment of Internal Medicine, St. Mary's Hospital, Isle of Wight National Health Service (NHS) Trust, Newport, GBR.
Guganesan VitushDepartment of General Surgery, St. Mary's Hospital, Isle of Wight National Health Service (NHS) Trust, Newport, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 35-year-old female patient was referred to General Medicine by Obstetrics for high calcium levels identified in routine postpartum lab tests. She had persistent vomiting throughout pregnancy and had been managed with antiemetics without lasting relief. On initial work-up, her parathyroid hormone (PTH) was found to be suppressed, suggesting a non-PTH-related etiology. Comprehensive investigations, including bone profile, erythrocyte sedimentation rate (ESR), myeloma screening, imaging (CT, PET), and respiratory evaluation, excluded malignancy, sarcoidosis, and other common causes. Despite a trial of intravenous (IV) fluids, low-dose steroids, and calcium management, the patient's condition persisted, necessitating referral to specialized centers. After exhaustive consultations, ectopic PTH secretion was identified as the likely cause of the elevated calcium levels. Given the challenges related to lactation and breastfeeding, the management required coordination between obstetrics, endocrinology, and maternity services to ultimately manage hypercalcemia. This case highlights the diagnostic complexity and the importance of an interdisciplinary approach in managing rare conditions like lactational hypercalcemia and ectopic PTH secretion in the postpartum period.

Indexed as

case reportectopic secretionlactational hypercalcemiaparathyroid hormonepostpartum hypercalcemia

Identifiers

PMID41487858
PMCPMC12756783

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.