ArticleCureus2025
Effect of Cardamom Oil After Acute and Repeated Administration in Albino Wistar Rats.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A full-spectrum aqueous extract of black cardamom (Frontiers in neuroscience · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose
methodsA single oral dose of cardamom oil at 300 and 2000 mg/kg was administered to female Wistar rats, and they were observed for signs of behavioural changes, mortality, and morbidity for 14 days. In the case of a repeated dose toxicity study of cardamom oil, doses of 50, 100, and 200 mg/kg were administered to rats for 28 days orally. The effect of cardamom oil on body weight, food intake, consumption of water, relative organ weight, hematological and urine parameters, and clinical biochemistry profile was studied. Histopathology and gross necropsy of vital organs were performed.
resultsIn an acute toxicity study, cardamom oil at a 300 mg/kg dose did not show any signs of toxicity. At a 2000 mg/kg dose, cardamom oil showed mortality in one animal, and the other two animals displayed mild signs of toxicity. Based on the results of the acute toxicity study, it can be concluded that the lethal dose (LD)₅₀ of cardamom oil is greater than 2000 mg/kg. In a repeated dose toxicity study, cardamom oil at 50, 100, and 200 mg/kg did not show any significant changes in body weight, food intake, water consumption, and relative organ weight. Cardamom oil did not show any significant changes in biochemical, renal, haematological parameters, and histopathological study as compared to the control group.
conclusionCardamom oil was found to be safe at 300 mg/kg in an acute toxicity study and at all selected dose levels in a repeated dose toxicity study in rats.
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Registered trials
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