ArticleCureus2025
Bladder Washing Cytology in the Detection of High-Grade Prostatic Adenocarcinoma: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Bladder washing cytology is a valuable diagnostic tool primarily used in the evaluation of urothelial malignancies. However, its role in detecting metastatic or secondary malignancies, such as high-grade prostatic adenocarcinoma, is less commonly recognized. We present the case of an 82-year-old man whose post-cystoscopy bladder washing cytology revealed atypical glandular cells. Immunocytochemical staining showed strong NKX3.1 nuclear positivity, suggesting a prostatic origin. Subsequent transurethral resection of the prostate confirmed high-grade prostatic adenocarcinoma with intraductal carcinoma and a cribriform growth pattern, classified as International Society of Urological Pathology (ISUP) Grade Group 4 (Gleason score 4+4=8). Notably, NKX3.1-positive malignant cells were also identified in a follow-up voided urine sample. This case underscores the potential utility of urine cytology, particularly when supplemented by immunocytochemistry, in the diagnosis of prostate cancer.
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