ArticleCureus2025
Inflammatory Bowel Disease and Mental Health: The Complex Relationship Between Gut and Brain.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Abbreviated non-contrast magnetic resonance enterography for Crohn's disease: a reliability study.La Radiologia medica · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe study sought to determine the association between IBD severity and mental health impact as measured by anxiety, depression, and QOL in our Pakistani patients. DESIGN AND
methodsA cross-sectional study was conducted with 400 IBD patients from clinics and community healthcare centres in Faisalabad, Dera Ismail Khan, and Karachi. Data were collected using the Short IBD Questionnaire (SIBDQ) and Hospital Anxiety and Depression Scale (HADS). Spearman correlations, chi-square tests, Mann-Whitney U, Kruskal-Wallis, and multiple regression analyses (SPSS v26) were performed.
resultsOf 400 participants, 240 (60%) were female, and most were aged 25-34 years (126, 31%). A total of 190 (47%) scored ≥11 on the HADS, indicating clinically significant anxiety or depression. SIBDQ and HADS scores were negatively correlated (ρ = -0.33, 95% CI -0.40 to -0.26, p < 0.001). Multiple regression showed that higher HADS scores were predicted by greater disease severity (B = 0.19, 95% CI 0.08-0.29, p = 0.001), female gender (B = 0.89, 95% CI 0.25-1.53, p = 0.007), younger age (B = -0.21, 95% CI -0.37 to -0.05, p = 0.011), disease activity (B = 0.44, 95% CI 0.14-0.74, p = 0.004), IBD type (B = 0.53, 95% CI 0.16-0.90, p = 0.006), and family history (B = 0.69, 95% CI 0.08-1.30, p = 0.026). Patients with severe IBD had the highest rates of clinically significant anxiety or depression (62% vs 43% in moderate and 10% in normal; χ²(4) = 81.9, p < 0.001). Females and younger participants reported greater disease severity and mental health burden (p < 0.01).
conclusionsAnxiety and depression are prevalent among Pakistani IBD patients, particularly in women, younger adults, and those with severe disease. These findings highlight the need for integrated gastroenterology-psychiatry care with routine mental health screening and psychosocial support to improve long-term outcomes and quality of life.
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