ArticleCureus2025
Prognostic Value of the Hematometabolic Index for Incident Metabolic Syndrome: Findings From a Large Occupational Cohort of Japanese Men.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWe have recently proposed the hematometabolic index (HMI), which was defined as the product of blood hemoglobin concentration and leukocyte count after modifications. HMI was associated with the risk of cardiovascular disease in a cross-sectional study. This study aimed to investigate the relationship between HMI and the onset of metabolic syndrome.
methodsA retrospective cohort study was conducted on 7254 adult men (31-75 years old) receiving annual health checkups to investigate the relationship between HMI and incident metabolic syndrome. The subjects were divided into four HMI quartile groups, and the crude and adjusted odds ratios of each quartile vs. the 1st quartile group for metabolic syndrome were estimated using logistic regression analysis.
resultsIn the baseline analysis using the data of subjects before follow-up, HMI showed significant positive relationships with the components of metabolic syndrome, including visceral obesity, hypertension, dyslipidemia (high triglycerides and/or low high-density lipoprotein cholesterol), and diabetes. The crude odds ratios for metabolic syndrome after a five-year follow-up of the 2nd, 3rd, and 4th quartile groups of HMI versus the 1st quartile group were 1.51 (1.16-1.96), 2.13 (1.66-2.73), and 3.02 (2.38-3.84), respectively, which were significantly higher than the reference level. The odds ratios remained significant after adjusting for age, histories of habitual smoking, alcohol consumption, and regular exercise, and the above components of metabolic syndrome at baseline.
conclusionHMI was associated with incident metabolic syndrome in this retrospective cohort study and is a possible predictor of cardiometabolic risk.
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