ArticleFrontiers in public health2025
High transmission risk in HIV-1 molecular transmission network among MSM is related to unsafe sexual behavior and adverse childhood experiences: a case-control study.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Molecular transmission networks enable successful identification of core transmitters compared to traditional epidemiological surveillance; however, behavioral characteristics and psychological drivers of these spreaders remain poorly characterized. Adverse childhood experiences (ACEs) are significantly more common among HIV-positive individuals than in the general population; yet empirical evidence showing that ACEs increase transmission risk among men who have sex with men (MSM) remains limited. This study investigates transmission risk in molecular network associations with sexual behaviors and adverse childhood experiences among MSM. Methods: This study was a Case-Control Study based on molecular networks. A molecular transmission network was constructed using HIV-1 pol sequences from 1,691 newly diagnosed MSM in Guangzhou (2018-2020). Cases were defined as individuals with a network degree ≥3 (high transmission risk group) and controls were defined as those with a degree <3 (low transmission risk group), matched 1:1 by age (±5 years). Data on sexual behavior and adverse childhood experiences were collected via electronic questionnaires from 2023 to 2024. Logistic regression was used to analyze associations between these factors and transmission risk. Results: Among 1,691 participants, 40.57% were included in the molecular network, comprising 238 high-risk and 448 low-risk individuals. After matching, 119 pairs were analyzed. High-risk MSM exhibited significantly elevated transmission risks associated with sexually transmitted infections (aOR = 2.947, 95% CI: 1.084-8.008); versatile sexual role (aOR = 2.856, 95% CI: 1.323-6.165); infrequent sexual activity (monthly: aOR = 6.487, 95% CI: 1.594-26.407; ≤quarterly: aOR = 6.708, 95% CI: 1.668-26.984); no stable partner or multiple stable partners (aOR = 2.516, 95% CI: 1.231-5.140); childhood sexual abuse (aOR = 2.791, 95% CI: 1.268-6.146); physical neglect (aOR = 2.386, 95% CI: 1.087-5.238). Conclusion: Unsafe sexual behavior and ACEs significantly increased the likelihood of becoming a core transmitter within MSM networks. Integrating screening for these factors into prevention programs could optimize early identification of high-transmission-risk MSM and enhance precision interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.