Evidence map›Paper›PMID 41487515›Full record

ArticleFrontiers in pharmacology2025

Inflammatory response in CF airway epithelial cells: a comparative study of modulators and wild-type CFTR rescue.

Amal Kouadri, Camille Lyko, Carine El Hajjar, Johanna Cormenier, Kevin Kevin Gemy, Nadia Alfaidy, Mohamed Benharouga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amal KouadriInstitut National de la Santé et de la Recherche Médicale (INSERM), U1292, Laboratoire de BioSanté, Grenoble, France.
Camille LykoInstitut National de la Santé et de la Recherche Médicale (INSERM), U1292, Laboratoire de BioSanté, Grenoble, France.
Carine El HajjarInstitut National de la Santé et de la Recherche Médicale (INSERM), U1292, Laboratoire de BioSanté, Grenoble, France.
Johanna CormenierInstitut National de la Santé et de la Recherche Médicale (INSERM), U1292, Laboratoire de BioSanté, Grenoble, France.
Kevin Kevin GemyInstitut National de la Santé et de la Recherche Médicale (INSERM), U1292, Laboratoire de BioSanté, Grenoble, France.
Nadia Alfaidy *Institut National de la Santé et de la Recherche Médicale (INSERM), U1292, Laboratoire de BioSanté, Grenoble, France.
Mohamed Benharouga *Institut National de la Santé et de la Recherche Médicale (INSERM), U1292, Laboratoire de BioSanté, Grenoble, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combination of pharmacological modulators such as lumacaftor, tezacaftor, and elexacaftor restore CFTR activity at the plasma membrane and improve lung function in patients carrying CFTR mutations such as F508del, their effects on inflammation are less clear. This study aimed to investigate whether the inflammatory response in CF airway epithelial cells depends solely on Cl

Indexed as

airway inflammationCFTR foldingCFTR proteincystic fibrosispharmacological correction

Identifiers

PMID41487515
PMCPMC12756383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.