ArticleFrontiers in pharmacology2025
A warming-yang herbal decoction protects against high-altitude hypoxia-induced osteoblast injury through modulation of HIF-1 signaling.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This paper systematically explored dental osteoblast injury at high altitude hypoxic condition and examined the protective role of warming-yang traditional medicine, Aconitum carm michaelii and Zingiber officinale decoction (GAWD) in this condition. Methods: We constructed an Results: Transcriptome profiling revealed that the hypoxia-inducible factor-1 (HIF-1) signaling pathway was central in the mediator role of osteoblast injury. High altitude hypoxia greatly suppressed the expression of HIF-1α, HIF-1β, von Hippel-Lindau tumor suppressor gene (VHL) and vascular endothelial growth factor (VEGF), resulting in increased intracellular ROS, calcium overload, mitochondrial distress, G Conclusion: The findings implicated HIF-1 signaling dysregulation in inducing high-altitude hypoxia-induced osteoblast injury and osteoporosis. GAWD may reduce hypoxia-induced cellular stress through recovering redox homeostasis and adjusting HIF-1/VEGF signaling. Collectively, this, study offers early molecular evidence supporting the utility of GAWD as a traditional Chinese medicine-based intervention for the prevention of bone metabolic disorders due to chronic hypoxic exposure.
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