Evidence map›Paper›PMID 41487449›Full record

ArticleJournal of arrhythmia2026

Safety and Efficacy of Pulsed Field Ablation for Atrial Fibrillation in Elderly Patients.

Federico Follesa, Alix Prévot, Samy Gribissa, Xavier Waintraub, Marine Thuillot, Nicolas Badenco, Guillaume Duthoit, Estelle Gandjbakhch, Mikael Laredo

Abstract read
In one paragraph

Article in Journal of arrhythmia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Clinical outcomes after catheter ablation for atrial fibrillation in elderly patients: a meta-analysis with time-to-event data reconstruction.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Federico FollesaSorbonne Université, Unité de Rythmologie, Institut de Cardiologie, AP-HP, Hôpital Universitaire Pitié-Salpêtrière Paris France.
Alix PrévotSorbonne Université, Unité de Rythmologie, Institut de Cardiologie, AP-HP, Hôpital Universitaire Pitié-Salpêtrière Paris France.
Samy GribissaSorbonne Université, Unité de Rythmologie, Institut de Cardiologie, AP-HP, Hôpital Universitaire Pitié-Salpêtrière Paris France.
Xavier WaintraubSorbonne Université, Unité de Rythmologie, Institut de Cardiologie, AP-HP, Hôpital Universitaire Pitié-Salpêtrière Paris France.
Marine ThuillotSorbonne Université, Unité de Rythmologie, Institut de Cardiologie, AP-HP, Hôpital Universitaire Pitié-Salpêtrière Paris France.
Nicolas BadencoSorbonne Université, Unité de Rythmologie, Institut de Cardiologie, AP-HP, Hôpital Universitaire Pitié-Salpêtrière Paris France.
Guillaume DuthoitSorbonne Université, Unité de Rythmologie, Institut de Cardiologie, AP-HP, Hôpital Universitaire Pitié-Salpêtrière Paris France.
Estelle GandjbakhchSorbonne Université, Unité de Rythmologie, Institut de Cardiologie, AP-HP, Hôpital Universitaire Pitié-Salpêtrière Paris France.ORCID https://orcid.org/0000-0002-4846-5021
Mikael LaredoSorbonne Université, Unité de Rythmologie, Institut de Cardiologie, AP-HP, Hôpital Universitaire Pitié-Salpêtrière Paris France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulsed-field ablation (PFA) is increasingly used for catheter ablation of atrial fibrillation (AF), but older patients remain underrepresented in clinical trials. This study aimed to compare procedural outcomes and mid-term effectiveness of PFA in patients aged ≤ 75 and > 75 years. Methods: In this retrospective single-center cohort, 479 consecutive patients underwent PFA for AF between January 2022 and April 2024. Patients were grouped by age (≤ 75 vs. > 75 years at ablation). Procedural parameters and acute complications were compared. Arrhythmia-free survival was assessed with Kaplan-Meier analysis after an 8-weeks blanking period, and predictors of recurrence were evaluated using Cox regressions. Results: Of 479 patients (mean age 65.0 ± 12.1 years; 73.6% males), 104 (21.7%) were > 75 years at ablation. Patients > 75 years had more comorbidities, including hypertension and impaired renal function. Pulmonary vein isolation was achieved in 99.8% of cases. Acute complication rates were similar between groups (7.7% in > 75 vs. 8.5% in ≤ 75, Conclusions: PFA in patients > 75 years is associated with low complication rates and favorable rhythm outcomes, comparable to those in younger patients. These findings support the use of PFA in elderly patients with AF.

Indexed as

Ablation safetyAgingAtrial ArrhythmiaCatheter ablationPentaspline catheter

Identifiers

PMID41487449
PMCPMC12759182

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.