ReviewFrontiers in neurology2025
Recent advances and evolving strategies in the treatment of lumbar disc herniation.
Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Dermatome-Specific Herpes Zoster Following Corticosteroid Therapy for Lumbar Disc Herniation: A Case Report Illustrating the Immunocompromised District Theory.Clinical case reports · 2026Article
- Efficacy and safety of low-temperature plasma ablation combined with collagenase in the treatment of lumbar disc herniation.BMC surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lumbar disc herniation (LDH) remains a leading cause of low back pain and sciatica, imposing a considerable global health and socioeconomic burden. Over the past decades, substantial progress has been made in both conservative and surgical interventions, yet controversies persist regarding optimal treatment strategies, long-term efficacy, and recurrence prevention. This review provides a comprehensive overview of current therapeutic approaches, including pharmacological management, physical therapy, minimally invasive and open surgical techniques, as well as emerging biological therapies. Special attention is given to platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and chemonucleolysis, which demonstrate potential in delaying disc degeneration and enhancing tissue repair. Moreover, we highlight the growing role of artificial intelligence (AI) in diagnosis, surgical planning, prognosis prediction, and rehabilitation monitoring, along with the increasing emphasis on multidisciplinary team (MDT) management. Finally, we discuss ongoing challenges, such as the need for standardized long-term outcome evaluation, individualized treatment pathways, and the clinical translation of regenerative medicine. By integrating traditional strategies with novel technologies, this review underscores the evolving paradigm of LDH management toward more minimally invasive, personalized, and multidisciplinary approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.