ArticleJournal of oral biology and craniofacial research
Evaluating the role of a novel homeodomain protein in periodontal regenerative therapy: An in-vitro study.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The goal of periodontal treatment is to halt disease progression and restore the structure and function of damaged periodontal tissues. Homeodomains-transcription factors prominently expressed during limb bud formation and craniofacial development-are abundantly present in the periosteum, and their expression continues in postnatal descendant cells, where they play a key role in bone homeostasis and fracture healing. These factors regulate stem cell differentiation critical for cementogenesis, osteogenesis, and periodontal ligament (PDL) regeneration, making them attractive targets for periodontal tissue engineering and regenerative therapies. A deeper understanding of homeodomain protein functions could lead to innovative treatments for periodontal disease and alveolar bone defects. In this context, our study investigated the role of homeodomain proteins in periodontal regeneration. Methods: Periosteum tissue was collected from a fracture site, and protein extracts were prepared. MTT and in vitro wound-healing assays were performed using a PDL cell line co-cultured with homeodomain protein (test group) and PDL cells alone (control group). Results: The MTT assay revealed that a concentration of 5 μg/mL yielded the highest cell viability. In the wound-healing assay, significant differences between the control and test groups demonstrated that homeodomain expression enhances cell migration and proliferation. Conclusion: Homeodomain protein expression in the periosteum could serve as a novel biomarker for periodontal regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.