Evidence map›Paper›PMID 41487300›Full record

ArticleJHLT open2026

Prognostic impact of restrictive ventilatory defects in chronic lung allograft dysfunction without restrictive allograft syndrome-like opacities: Stratification of emerging undefined and unclassified phenotypes.

Taiki Fukuda, Yusei Nakamura, Yuki Ko, Shu-Chi Tseng, Staci M Gagne, Takeshi Johkoh, Yi Li, David C Christiani, Hiroya Ojiri, Lynette Sholl and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Taiki FukudaCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Yusei NakamuraCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Yuki KoCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Shu-Chi TsengDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan City, Taiwan.
Staci M GagneCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Takeshi JohkohDepartment of Radiology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.
Yi LiDepartment of Biostatistics, University of Michigan, Ann Arbor, MI.
David C ChristianiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Hiroya OjiriDepartment of Radiology, The Jikei University School of Medicine, Tokyo, Japan.
Lynette ShollDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Mizuki NishinoCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Hiroto HatabuCenter for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Funding

Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
New Statistical Methods for Modelling Cancer OutcomesR01CA249096 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yi Li · 2021 to 2026
$2.5M
Detecting racial disparities in cancer survival by integrating multiple high-dimensional observational studiesR01CA269398 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUHA, SUBHARUP, LI, YI · 2022 to 2025
$1.3M
NCI NIH HHS R01 CA249096NCI NIH HHS R01 CA269398NCI NIH HHS R35 CA197449
6 · The paper itself

Abstract

Background: Chronic lung allograft dysfunction (CLAD) remains a critical factor affecting post-lung transplant prognosis. While RAS-like opacities (RLO) are established as poor prognostic indicators, prognostic stratification of non-RLO CLAD cases, including undefined and unclassified phenotypes per the 2019 International Society for Heart and Lung Transplantation (ISHLT) criteria, remains unexplored. Methods: We retrospectively analyzed 241 bilateral lung transplant recipients between 2005 and 2021. CLAD was diagnosed and classified per the 2019 ISHLT criteria. Non-RLO patients were stratified by restrictive ventilatory defects for survival analysis. Diaphragmatic elevation and pleural effusion were also evaluated as potential causes of restrictive physiology and their prognostic significance. Results: Of 83 CLAD patients, 61 (73.5%) had no RLO. In multivariable Cox analysis of non-RLO patients, restrictive ventilatory defects showed a trend toward worse outcomes (Hazard ratio [HR]: 2.56, 95% CI: 0.98-6.71; Conclusions: Non-RLO CLAD patients with restrictive ventilatory defects demonstrated significantly increased cumulative incidence of death (retransplantation as a competing risk), challenging the assumption that all non-RLO cases follow a favorable BOS-like prognosis. Pleural effusion was identified as a significant independent prognostic marker.

Indexed as

Baseline lung allograft dysfunctionChronic lung allograft dysfunctionLung transplantationPhenotypesPleural effusionPrognosisRestrictive

Identifiers

PMID41487300
PMCPMC12757451

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.