ArticleFrontiers in bioinformatics2025
Network-based insights into miR-30a-5p-mediated regulation and EGCG targeting in triple-negative breast cancer.
Article in Frontiers in bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Circulating miRNA-30a is associated with favorable therapeutic outcome in patients with gastric cancer treated with neoadjuvant chemotherapy.Oncology letters · 2026Article
- Repurposing natural compounds: computational evaluation ofFrontiers in bioinformatics · 2026Article
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Authors and funding
2 authors.
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Abstract
Background: Triple-negative breast cancer (TNBC) is defined by the absence of ER, PR, and HER2 expression. This limits the targeted therapies, resulting in poor clinical outcomes. Identifying the molecular targets that can be regulated through miRNAs and natural compounds offers a potential therapeutic platform. Methods: We combined transcriptomic profiling with miRNA target prediction to identify genes regulated by miR-30a-5p and assess their interaction with the green tea polyphenol, epigallocatechin gallate (EGCG). Differentially expressed genes (DEGs) from TCGA-TNBC datasets and miRNA targets from miRDB, TargetScan, and miRTarBase were screened for common genes. Then, the protein-protein interaction and network topology analyses were performed to identify key hub genes. Molecular docking and simulation were carried out with the four key genes against EGCG. Results: Data integration yielded 393 overlapping genes and identified ten hub genes- Conclusion: The results emphasizes that EGCG has strong binding affinity towards YWHAZ, revealing that miR-30a-EGCG targets TNBC synergistically through cell-cycle-mediated pathways. The findings give rational support for miRNA-guided phytochemical-based TNBC therapeutic development.
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