Evidence map›Paper›PMID 41487256›Full record

ArticleACS omega2025

Site-Selective Protein Modification via Peptide-Directed Proximity Catalysis.

Laetitia Raynal, Joe Nabarro, Lisa M Miller, Adam A Dowle, Sophie L Moul, Phathutshedzo Masithi, Steven D Johnson, Martin A Fascione, Christopher D Spicer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Expediated synthesis ofOrganic & biomolecular chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laetitia RaynalDepartment of Chemistry, University of York, Heslington YO10 5DD, U.K.
Joe NabarroDepartment of Chemistry, University of York, Heslington YO10 5DD, U.K.
Lisa M MillerYork Biomedical Research Institute, University of York, Heslington YO10 5DD, U.K.ORCID https://orcid.org/0000-0003-3667-3840
Adam A DowleBioscience Technology Facility, Department of Biology, University of York, Heslington YO10 5DD, U.K.ORCID https://orcid.org/0000-0002-6501-5444
Sophie L MoulDepartment of Chemistry, University of York, Heslington YO10 5DD, U.K.
Phathutshedzo MasithiDepartment of Chemistry, University of York, Heslington YO10 5DD, U.K.
Steven D JohnsonYork Biomedical Research Institute, University of York, Heslington YO10 5DD, U.K.ORCID https://orcid.org/0000-0002-1786-3182
Martin A FascioneDepartment of Chemistry, University of York, Heslington YO10 5DD, U.K.ORCID https://orcid.org/0000-0002-0066-4419
Christopher D SpicerDepartment of Chemistry, University of York, Heslington YO10 5DD, U.K.ORCID https://orcid.org/0000-0001-8787-578X

Funding

Wellcome Trust 225257
6 · The paper itself

Abstract

Proximity catalysis exploits ligand binding for localized, catalytic protein modification. In this work, we introduce catalyst-functionalized peptides as versatile ligands for this approach. Through the functionalization of target-binding peptides with pyridinium oxime catalysts, we show that model proteins can be site-selectively modified with a variety of

Identifiers

PMID41487256
PMCPMC12756790

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.