Evidence map›Paper›PMID 41487215›Full record

ArticleACS omega2025

Toward Cartilage-Mimicking Biomaterials: Biotribological, Biochemical and Structural Evaluation of pHEMA and PVA-Based Hydrogels.

David Nečas, Daniel Němeček, Jan Gregora, David Rebenda, Zuzana Kadlecová, Ivana Chamradová, Monika Trudičová, Pavel Čípek, Petr Čípek, Ladislav Šnajdárek and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

David NečasDepartment of Tribology, Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.ORCID https://orcid.org/0000-0002-3843-8732
Daniel NěmečekDepartment of Tribology, Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.
Jan GregoraDepartment of Tribology, Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.
David RebendaDepartment of Tribology, Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.ORCID https://orcid.org/0000-0002-5407-1336
Zuzana KadlecováAdvanced Biomaterials, Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, 612 00 Brno, Czech Republic.ORCID https://orcid.org/0009-0009-6693-1055
Ivana ChamradováAdvanced Biomaterials, Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, 612 00 Brno, Czech Republic.
Monika TrudičováAdvanced Biomaterials, Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, 612 00 Brno, Czech Republic.
Pavel ČípekDepartment of Tribology, Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.
Petr ČípekDepartment of Tribology, Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.
Ladislav ŠnajdárekDepartment of Tribology, Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.
Lucy VojtováAdvanced Biomaterials, Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, 612 00 Brno, Czech Republic.ORCID https://orcid.org/0000-0001-5281-7045
Martin VrbkaDepartment of Tribology, Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.
Ivan KřupkaDepartment of Tribology, Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.
Martin HartlDepartment of Tribology, Faculty of Mechanical Engineering, Brno University of Technology, Technická 2896/2, 616 69 Brno, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study compares the biotribological and structural behavior of PVA and pHEMA hydrogels under conditions simulating the cartilage environment to understand the lubrication mechanisms. PVA samples exhibited very low apparent friction coefficients and high-water uptake due to their hydrophilic, hydroxyl-rich network. In contrast, pHEMA hydrogels showed higher friction but substantially enhanced wear resistance, particularly under extended sliding against rough counterfaces. While PVA offers excellent lubrication performance, its wear stability remains limited. On the other hand, the low wear observed in pHEMAdespite its higher frictionsuggests strong structural resilience, making it a promising platform for further tailoring toward cartilage-mimicking applications. The results highlight the importance of balancing interfacial lubrication and mechanical durability when designing hydrogel-based cartilage replacements.

Identifiers

PMID41487215
PMCPMC12756760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.